Pharm Sciences Lab  




Dr. Anand Iyer           Dr. Neelam Azad




Recent Publications




Kaushik V, Yakisich JS, Way LF, Azad N, Iyer AKV. Chemoresistance of cancer floating cells is independent of their ability to form 3D structures: Implications for anticancer drug screening. J Cell Physiol. 2018 Sep 7. doi: 10.1002/jcp.27239. [Epub ahead of print]


Kulkarni YM, Dutta S, Iyer AKV, Wright CA, Ramesh V, Kaushik V, Semmes OJ, Azad N. A Lipidomics Approach to Identifying Key Lipid Species Involved in VEGF-Inhibitor Mediated Attenuation of Bleomycin-Induced Pulmonary Fibrosis. Proteomics Clin Appl. 2017 Dec 28. doi: 10.1002/prca.201700086.



Yakisich JS, Kulkarni Y, Azad N, Iyer AKV. Selective and Irreversible Induction of Necroptotic Cell Death in Lung Tumorspheres by Short-Term Exposure to Verapamil in Combination with Sorafenib. Stem Cells Int. 2017;2017:5987015. doi: 10.1155/2017/5987015



Guishard AF, Yakisich JS, Azad N, Iyer AKV. Translational gap in ongoing clinical trials for glioma. J Clin Neurosci. 2018 Jan;47:28-42. doi: 10.1016/j.jocn.2017.10.001.



Venkatadri R, Iyer AKV, Kaushik V, Azad N. A novel resveratrol-salinomycin combination sensitizes ER-positive breast cancer cells to apoptosis. Pharmacol Rep. 2017 Aug;69(4):788-797.



Kulkarni YM, Yakisich JS, Azad N, Venkatadri R, Kaushik V, O'Doherty G, Iyer AKV. Anti-tumorigenic effects of a novel digitoxin derivative on both estrogen receptor-positive and triple-negative breast cancer cells .Tumour Biol. 2017 Jun;39(6):1010428317705331. doi: 10.1177/1010428317705331.



Wright C, Iyer AK, Kaushik V, Azad N. Anti-Tumorigenic Potential of a Novel Orlistat-AICAR Combination in Prostate Cancer Cells. J Cell Biochem. 2017 Apr 7. doi: 10.1002/jcb.26033



Yakisich JS, Azad N, Kaushik V, O'Doherty GA, Iyer AK. Nigericin decreases the viability of multidrug-resistant cancer cells and lung tumorspheres and potentiates the effects of cardiac glycosides. Tumour Biol. 2017 Mar;39(3):1010428317694310. doi: 10.1177/1010428317694310.



Wright C, Iyer AK, Yakisich JS, Azad N.Anti-Tumorigenic Effects of Resveratrol in Lung Cancer Cells Through Modulation of c-FLIP. Curr Cancer Drug Targets. 2017 Mar 15. doi: 10.2174/1568009617666170315162932



Yakisich JS, Venkatadri R, Azad N, Iyer AK. Chemoresistance of Lung and Breast Cancer Cells Growing Under Prolonged Periods of Serum Starvation. J Cell Physiol. 2016 Aug 9. doi: 10.1002/jc



Kaushik V, Azad N, Yakisich JS, Iyer AK. Antitumor effects of naturally occurring cardiac glycosides convallatoxin and peruvoside on human ER+ and triple-negative breast cancers. Cell Death Discov. 2017 Feb 27;3:17009. doi: 10.1038/cddiscovery.2017.9.



Yakisich JS, Azad N, Kaushik V, Iyer AK. Cancer Cell Plasticity: Rapid Reversal of Chemosensitivity and Expression of Stemness Markers in Lung and Breast Cancer Tumorspheres.J Cell Physiol. 2016 Dec 7. doi: 10.1002/jcp.25725



Wright C, Iyer AK, Wang L, Wu N, Yakisich JS, Rojanasakul Y, Azad N. Effects of titanium dioxide nanoparticles on human keratinocytes. Drug Chem Toxicol. 2016 Jun 16:1-11.



Venkatadri R, Muni T, Iyer AK, Yakisich JS, Azad N. (2016) Role of apoptosis-related miRNAs in resveratrol-induced breast cancer cell death. Cell Death Dis. 2016 Feb 18;7:e2104. doi: 10.1038/cddis.2016.6.



Kaushik V, Yakisich JS, Azad N, Kulkarni Y, Venkatadri R, Wright C, Rojanasakul Y, Iyer AK.Anti-Tumor Effects of Cardiac Glycosides on Human Lung Cancer Cells and Lung Tumorspheres. J Cell Physiol. 2016 Sep 23. doi: 10.1002/jcp.25611.



Venkatadri R, Iyer AK, Ramesh V, Wright C, Castro CA, Yakisich JS, Azad N.MnTBAP Inhibits Bleomycin-Induced Pulmonary Fibrosis by Regulating VEGF and Wnt Signaling. J Cell Physiol. 2017 Mar;232(3):506-516. doi: 10.1002/jcp.25608



Klionsky DJ, Abdelmohsen K, Abe A,  Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD et al., (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222.



Yakisich JS, Azad N, Venkatadri R, Kulkarni Y, Wright C, Kaushik V, Iyer AK. (2016) Formation of Tumorspheres with Increased Stemness without External Mitogens in a Lung Cancer Model. Stem Cells Int. 2016:5603135. doi: 10.1155/2016/5603135.



Yakisich JS, Azad N, Venkatadri R, Kulkarni Y, Wright C, Kaushik V, O'Doherty GA, Iyer AK.(2016) Digitoxin and its synthetic analog MonoD have potent antiproliferative effects on lung cancer cells and potentiate the effects of hydroxyurea and paclitaxel. Oncol Rep.  35: 878-886 Nov 12. doi: 10.3892/or.2015.4416



Kulkarni YM, Dutta S, Iyer AK, Venkatadri R, Kaushik V, Ramesh V, Wright CA, Semmes OJ, Yakisich JS, Azad N. (2016) A Proteomics approach to identifying key protein targets involved in vegf-inhibitor mediated attenuation of bleomycin-induced pulmonary fibrosis. Proteomics 16:33-46. doi: 10.1002/pmic.201500171



Kulkarni YM, Kaushik V, Azad N, Wright C, Rojanasakul Y, O'Doherty G, Iyer AK. (2016) Autophagy-Induced Apoptosis in Lung Cancer Cells By a Novel Digitoxin Analog. J Cell Physiol. 2016 Apr;231(4):817-28. doi: 10.1002/jcp.25129.



Wright C, Iyer AK, Kulkarni Y, Azad N. (2016) S-Nitrosylation of Bcl-2 Negatively Affects Autophagy in Lung Epithelial Cells. J Cell Biochem. 2016 Feb;117(2):521-32. doi: 10.1002/jcb.25303.



Iyer AK, Ramesh V, Castro CA, Kaushik V, Kulkarni YM, Wright CA, Venkatadri R, Rojanasakul Y, Azad N. (2015) Nitric Oxide Mediates Bleomycin-induced Angiogenesis and Pulmonary Fibrosis via Regulation of VEGF. J Cell Biochem.  116(11):2484-93.



Iyer AK, Rojanasakul Y, Azad N. (2014) Nitrosothiol signaling and protein nitrosation in cell death. Nitric Oxide. 15;42:9-18.




Pharm Sciences Lab 2014 - 2018